Advanced Therapies in Regenerative Medicine

The aim of the second volume in this series is to provide the reader with a current update on the latest therapeutic developments.

Author: Jan-Thorsten Schantz

Publisher: World Scientific Publishing Company

ISBN: 9789814630665

Category: Science

Page: 300

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Regenerative medicine is a fast developing field which has led to a paradigm shift in treatment of various diseases. Clinician-scientists worldwide constantly develop novel approaches in various medical specialties (surgery, internal medicine, oncology, neurology, gynecology, pediatrics, etc.) using gene therapy approaches, innovative biomaterials or stem cell based therapies. It is difficult even for experts to find out what has already reached a clinical stage. The aim of the second volume in this series is to provide the reader with a current update on the latest therapeutic developments. As such, both patients and doctors will find the information contained within this manual to be useful and relevant. The editors are both international leaders in the field of regenerative medicine, and both possess a broad spectrum of experience from basic research to clinical application and commercialization.

Advanced Therapies for Cardiac Regeneration

Editorial: Advanced. Therapies. for. Cardiac. Regeneration. Monica Boffito 1*,
Susanna Sartori 1*, Ipsita Roy 2*, Irene ... The University of Sheffield, Sheffield,
United Kingdom Keywords: cardiac tissue engineering, regenerative medicine, ...

Author: Valeria Chiono

Publisher: Frontiers Media SA

ISBN: 9782889666959

Category: Science

Page:

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Regenerative Medicine from Protocol to Patient

This collection of volumes on Regenerative Medicine: From Protocol to Patient, aims to explain the scientific knowledge and emerging technology as well as the clinical application in different organ systems and diseases.

Author: Gustav Steinhoff

Publisher: Springer

ISBN: 9783319276106

Category: Science

Page: 455

View: 834

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Regenerative medicine is the main field of groundbreaking medical development and therapy using knowledge from developmental and stem cell biology, as well as advanced molecular and cellular techniques. This collection of volumes on Regenerative Medicine: From Protocol to Patient, aims to explain the scientific knowledge and emerging technology as well as the clinical application in different organ systems and diseases. International leading experts from all over the world describe the latest scientific and clinical knowledge of the field of regenerative medicine. The process of translating science of laboratory protocols into therapies is explained in sections on regulatory, ethical and industrial issues. This collection is organized into five volumes: (1) Biology of Tissue Regeneration, (2) Stem Cell Science and Technology, (3) Tissue Engineering, Biomaterials and Nanotechnology, (4) Regenerative Therapies I, and (5) Regenerative Therapies II. The textbook gives the student, the researcher, the health care professional, the physician and the patient a complete survey on the current scientific basis, therapeutical protocols, clinical translation and practiced therapies in regenerative medicine. Volume 2 contains sixteen chapters addressing advanced knowledge on “Stem Cell Science and Technology” addressing basic classification technology, cell biology of stemness state and regulatory molecular pathways. Mechanisms and technology of cell programming are explained, as well as the pathology of cancer cells and dedifferentiation signalling. Pluripotent, multipotent germline and tissue specific human stem cells are classified and qualified according to their respective biological function or tissue regeneration. Leading stem cell scientists from all over the world explain advanced technology, latest knowledge, and clinical implications of human stem cell science in a unique, comprehensive and detailed outline.

Principles of Regenerative Medicine

Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart ...

Author: Anthony Atala

Publisher: Academic Press

ISBN: 0080555950

Category: Science

Page: 1472

View: 752

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Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. * Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology * The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine * New discoveries from leading researchers on restoration of diseased tissues and organs

Clinical Translation and Commercialisation of Advanced Therapy Medicinal Products

Dr. Yves Bayon is a Senior Principal Scientist at Medtronic and Dr. Alain Vertes is affiliated with NxR Biotechnologies GmbH. All other Topic Editors declare no competing interests with regards to the Research Topic subject.

Author: Tracy Tong Li Yu

Publisher: Frontiers Media SA

ISBN: 9782889664146

Category: Science

Page:

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Dr. Yves Bayon is a Senior Principal Scientist at Medtronic and Dr. Alain Vertes is affiliated with NxR Biotechnologies GmbH. All other Topic Editors declare no competing interests with regards to the Research Topic subject.

Safety Ethics and Regulations

Saftey, Ethics, and Regulations and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue ...

Author: Phuc Van Pham

Publisher: Springer

ISBN: 9783319591650

Category: Science

Page: 327

View: 704

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This invaluable resource discusses the saftey, ethics, and regulations of developing stem cell clinical applications. Each chapter is contributed by a preeminent scientist in the field and covers such topics as clinical safety of stem cell gene therapy, the patentability of hESC technologies, international guidelines, challenges to international stem cell clinical trials, worldwide regulations including in emerging markets like China and Taiwan. Saftey, Ethics, and Regulations and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.

Proceedings of 9th International Conference and Exhibition on Advanced Cell and Gene Therapy 2019

March 21-22, 2019 , Rome, Italy Key Topics : Cell Therapy,Gene Therapy,Stem Cell Therapies,Cell Culture and Bioprocessing,Viral Gene Therapy,Cell and Gene Therapy for Rare & Common Diseases,Tissue Science & Regenerative Medicine,Molecular ...

Author: ConferenceSeries

Publisher: ConferenceSeries

ISBN:

Category: Medical

Page: 50

View: 391

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March 21-22, 2019 , Rome, Italy Key Topics : Cell Therapy,Gene Therapy,Stem Cell Therapies,Cell Culture and Bioprocessing,Viral Gene Therapy,Cell and Gene Therapy for Rare & Common Diseases,Tissue Science & Regenerative Medicine,Molecular Basis of Epigenetics,Bioengineering Therapeutics,Cell Science and Stem Cell Research,Clinical Trials on Cell & Gene Therapy,Nano Therapy,Genetic Engineering,Advanced Gene Therapeutics,Genetics & Genomic Medicine,Ethical Issues in Cell and Gene Therapy,Cell Therapy for Cardiovascular and Neurological Disorders,Regulatory and Safety Aspects of Cell and Gene Therapy,Markets & Future Prospects for Cell & Gene Therapy,Commercialization,

Genetic Engineering Biotechnology News

Stem Cell of its new SIG , “ Bioprocessing for Advanced Therapies ” in &
Regenerative Medicine International , a joint venture Edinburgh . The meeting
was organized in collaboration between Advanced Cell Techwith the Scottish
Stem Cell ...

Author:

Publisher:

ISBN: PSU:000059773535

Category: Biotechnology

Page:

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Advanced Therapeutics in Pain Medicine

This book is dedicated to the advancement of non-opioid therapeutic options that offer real progress in reaching a future of better pain management.

Author: Sahar Swidan

Publisher: CRC Press

ISBN: 9780429998263

Category: Health & Fitness

Page: 392

View: 369

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Chronic pain places a tremendous burden on both the patient and the healthcare system. The use of opioids to address pain has resulted in negative impacts. As practitioners work to undo the current opioid crisis, options to manage pain need a new approach. Advanced Therapeutics in Pain Medicine offers pioneering approaches to this intransigent problem providing a functional medicine approach toward treating pain. This book is dedicated to the advancement of non-opioid therapeutic options that offer real progress in reaching a future of better pain management. With an emphasis on pathophysiology, chapters review various types of pain and propose comprehensive treatment plans. These include manual therapies, novel pharmacologic and plant-based approaches, hormonal effects on pain pathways, as well as psychological and lifestyle interventions. Features · Written by a multi-discplinary team, the book provides clinicians with multiple non-opioid treatment considerations. · Enables practitioners to shift from a “one size fits all’ treatment approach toward individualized patient care. · Includes case studies to help educate the provider on how to implement treatment plans in practice. Written by a team of physicians, pharmacists, psychologists and researchers, this important book offers a much needed step forward in optimizing pain care and benefits practitioners who care for patients experiencing chronic pain.

Advanced Therapy in Cardiac Surgery

Strategies and Specific Interventions Constituting the New York Hospital - Cornell
Medical Center Blood Conservation ... generation / regeneration , ( 2 ) minimize
unnecessary hemodilution , ( 3 ) minimize autologous blood loss / maximize ...

Author: Kenneth L. Franco

Publisher:

ISBN: NWU:35558004200933

Category: Chest

Page: 543

View: 963

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This volume draws on the experience of leading practitioners to offer proven management techniques for cardiac surgery. It uses the case study approach to closely mirror clinical practice and treatment. First, cases that are specific to type or etiology are presented. Then, the case author explains how the case was managed. Suggestions regarding the management of similar cases are described. Lastly, vital information is summarized in a quick-reference format.

Challenges and Potential in Regenerative Medicine

Regenerative medicine comprises novel interdisciplinary approaches, including several based on cell and gene therapies, aimed at tissue regeneration and repair.

Author:

Publisher:

ISBN: 3804741444

Category:

Page:

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Regenerative medicine comprises novel interdisciplinary approaches, including several based on cell and gene therapies, aimed at tissue regeneration and repair. All regenerative medicine strategies depend upon harnessing, stimulating, guiding or replacing endogenous developmental or repair processes. Regenerative medicine offers significant promise for treating intractable diseases but, so far, has proved itself in only a few specific clinical indications, for example for haematopoietic and skin disorders. Stem-cell-based medicine is now established and will undoubtedly advance towards treating a progressively larger spectrum of diseases, so it is essential to address some critical scientific issues for evidence-based implementation and regulation. The consequences of not doing this would be to waste investment, researcher activity and aspirations to cure, as well as to undermine patient protection. This report, from a project conducted by EASAC (European Academies' Science Advisory Council) and FEAM (Federation of European Academies of Medicine), explores opportunities and challenges in this rapidly advancing field, discusses what principles should be offered for guidance in policy development and what the strategic priorities are in the European Union (EU) for products in the category of advanced therapy medicinal products, which includes those used for regenerative medicine.
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Dental Stem Cells

This book explores Dental Stem Cell (DSC) biology, from a review of basic concepts for cell culture, to isolation, self-renewal, multipotency and differentiation, regulation by molecular medicine, and prospective research areas for ...

Author: Fikrettin Şahin

Publisher: Springer

ISBN: 9783319289472

Category: Science

Page: 317

View: 682

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This book explores Dental Stem Cell (DSC) biology, from a review of basic concepts for cell culture, to isolation, self-renewal, multipotency and differentiation, regulation by molecular medicine, and prospective research areas for regenerative medicine. The first seven chapters delve into basic DSC properties, vital signaling pathways involved in differentiation, pluripotency, iPS cell development from DSCs, and genetic engineering approaches of DSCs in accordance with the current literature. A comprehensive review of possible clinical applications and in vitro/in vivo studies follows, illustrating the future of DSC research for in the tissue engineering field. The text also discusses the political, ethical, social, and legal ramifications of the use of dental stem cells. Expertly authored and drawing from a multitude of international perspectives, Dental Stem Cells is an invaluable addition to Springer’s Stem Cell Biology and Regenerative Medicine series. It is essential reading for advanced graduate students, basic researchers, and clinical investigators in the fields of stem cell therapy, biological sciences of dentistry, and regenerative medicine.

Mesenchymal Stem Cell Therapy

This text is a resource for both the basic life science and cell therapy researchers and includes a spectrum of review chapters from top experts in the field discussing clinical scale culture, regulatory issues, genetic engineering, disease ...

Author: Lucas G. Chase

Publisher: Springer Science & Business Media

ISBN: 9781627032001

Category: Science

Page: 456

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Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.

Neural Regenerative Nanomedicine

As current research is at the forefront of healing the nervous system, the content in the book focuses on basic, translational and clinical research in neural repair and regeneration.

Author: Mehdi Razavi

Publisher: Academic Press

ISBN: 9780128204467

Category: Science

Page: 318

View: 140

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Neural Regenerative Nanomedicine presents novel, significant, experimental results relating to nanoscience and nanotechnology in neural regeneration. As current research is at the forefront of healing the nervous system, the content in the book focuses on basic, translational and clinical research in neural repair and regeneration. Chapters focus on stem cell biology to advance medical therapies for devastating disorders, the complex, delicate structures that make up the nervous system, and neurodegenerative diseases that cause progressive deterioration, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), multiple sclerosis and multiple system atrophy. Presents a multidisciplinary focus on all research areas surrounding the applications of nanotechnology in neural regeneration Provides a guide for physician and scientists, including necessary expertise for bioengineers, materials engineers, those in biomaterials and nanoengineering, stem cell biologists, and chemists Covers many disciplines, including bioengineering, biomaterials, tissue engineering, regenerative medicine, neural regenerative medicine, and nanomedicine

Nature

Translational research in the fields of cell therapy and regenerative medicine ,
genomic medicine , and nanomedicine seem to hold a key role to this riddle . As
a result , the Regional Government of Andalucía steers the Andalusian Advanced
 ...

Author: Sir Norman Lockyer

Publisher:

ISBN: UOM:49015003312338

Category: Electronic journals

Page:

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Guide to Cell Therapy GxP

This book is also a thorough resource for PhD students, Post-docs, Principal Investigators, Quality Assurance Units, and Government Inspectors who want to learn more about how quality standards are implemented in public institutions ...

Author: Joaquim Vives

Publisher: Academic Press

ISBN: 9780128031162

Category: Medical

Page: 266

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Guide to Cell Therapy GxP is a practical guide to the implementation of quality assurance systems for the successful performance of all cell-based clinical trials. The book covers all information that needs to be included in investigational medicinal product dossier (IMPD), the launching point for any clinical investigation, and beyond. Guide to Cell Therapy GxP bridges a knowledge gap with the inclusion of examples of design of GLP-compliant preclinical studies; design of bioprocesses for autologous/allogeneic therapies; and instruction on how to implement GLP/GMP standards in centers accredited with other quality assurance standards. Guide to Cell Therapy GxP is an essential resource for scientists and researchers in hospitals, transfusion centers, tissue banks, and other research institutes who may not be familiar with the good scientific practice regulations that were originally designed for product development in corporate environments. This book is also a thorough resource for PhD students, Post-docs, Principal Investigators, Quality Assurance Units, and Government Inspectors who want to learn more about how quality standards are implemented in public institutions developing cell-based products. Easy access to important information on current regulations, state-of-the-art techniques, and recent advances otherwise scattered on various funding websites, within conference proceedings, or maintained in local knowledge Features protocols, techniques for trouble-shooting common problems, and an explanation of the advantages and limitations of a technique in generating conclusive data Includes practical examples of successful implementation of quality standards

Biomaterials from Nature for Advanced Devices and Therapies

Edited by world-leading experts with contributions from top-notch international scientists, it collates the experience and cutting-edge knowledge on natural biomaterials from all over the world, making the book a must-have publication on ...

Author: Nuno M. Neves

Publisher: John Wiley & Sons

ISBN: 9781118478059

Category: Medical

Page: 704

View: 380

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In-depth information on natural biomaterials and their applications for translational medicine! Undiluted expertise: edited by world-leading experts with contributions from top-notch international scientists, collating experience and cutting-edge knowledge on natural biomaterials from all over the world A must-have on the shelf in every biomaterials lab: graduate and PhD students beginning their career in biomaterials science and experienced researchers and practitioners alike will turn to this comprehensive reference in their daily work Link to clinical practice: chapters on translational research make readers aware of what needs to be considered when a biomaterial leaves the lab to be routinely used

New Delivery Systems for Controlled Drug from Naturally Occuring Materials

Tissue Engineering Necessary for Regenerative Medical Therapy As surgical
therapies currently available, there are reconstruction surgery and organ
transplantation. Although it is no doubt that these advanced therapies have
saved and ...

Author: Nicholas Parris

Publisher: Amer Chemical Society

ISBN: UOM:39015082228878

Category: Medical

Page: 323

View: 664

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This book is directed toward the use of natural materials in the development of novel drug delivery systems and regeneration technologies

Terapias Biol gicas En Cirug a Ortop dica

En vez de crear la vía 351B, la 21st Century Cures Act creó la denominación
Regenerative Medicine Advanced Therapy (RMAT). Esta puede ser solicitada
por los patrocinadores de la tecnología al mismo tiempo que una solicitud IND o
como ...

Author: Augustus D. Mazzocca

Publisher: Elsevier

ISBN: 9788491138044

Category:

Page: 232

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Acorta la brecha entre la investigación y el entorno clínico, proporcionando consejos prácticos sobre el uso de los descubrimientos recientes en la práctica real. Cubre aplicaciones en medicina deportiva, ortopedia general y oncología músculoesquelética. Aborda temas clave como la regulación integral, la osteoartritis, el trasplante de menisco, la ingeniería regenerativa y mucho más. Consolida la información disponible hoy día sobre este tema. Revisa la ciencia básica que apoya el uso de biológicos en la cirugía ortopédica. Muestra los éxitos y fracasos de los tratamientos biológicos en las diferentes subespecialidades de la medicina ortopédica. Libro que acorta la brecha entre la investigación y el entorno clínico y que proporciona consejos prácticos sobre el uso de los descubrimientos recientes en la práctica real. Repasa la ciencia básica que avala el uso de productos biológicos en traumatología y en cirugía ortopédica. Demuestra los éxitos y los fracasos de los tratamientos biológicos en las diferentes subespecialidades de la medicina ortopédica. Expone al lector el trabajo con mayor potencial para los pacientes abordando temas clave como la osteoartritis, la ingeniería regenerativa en cirugía ortopédica o las aplicaciones en oncología musculoesquelética.
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California Institute for Regenerative Medicine

For the May 25, 2006, conference, "Funding Structures to Advance Stem Cell
Research and Therapy,” presenters included affiliations with the University of
Ottawa, National Institute of Standards and Technology, Juvenile Diabetes
Research ...

Author: California. Bureau of State Audits

Publisher:

ISBN: UCSD:31822030370738

Category:

Page: 97

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