Protein Interactions As Targets in Drug Discovery

291 References 292 Abstract Protein-protein interactions are central to biology
and provide opportunities to modulate disease with small-molecule or protein
therapeutics. Recent developments in the understanding of the tractability of ...

Author: Rossen Donev

Publisher: Academic Press

ISBN: 9780128168462

Category:

Page: 264

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Protein Interactions as Targets in Drug Discovery, Volume 121, is dedicated to the design of therapeutics, both experimental and computational, that target protein interactions. Chapters in this new release include Trends in structure based drug design with protein targets, From fragment- to peptide-protein interaction: addressing the structural basis of binding using Supervised Molecular Dynamics (SuMD), Protein-protein and protein-ligand interactions: identification of potential inhibitors through computational analysis, Aromatic-aromatic interactions in protein-drug and protein-protein interactions, Role of protein-protein interaction in allosteric drug design within the human methyltransferome, and much more.
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DNA Protein Interactions

The binding of proteins to DNA and the manipulation of DNA by proteins are crucial aspects of the biological role of DNA in the living cell. This book provides a comprehensive and lucid discussion of the molecular interactions involved.

Author: A. Travers

Publisher: Springer Science & Business Media

ISBN: 0412259907

Category: Medical

Page: 180

View: 241

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The binding of proteins to DNA and the manipulation of DNA by proteins are crucial aspects of the biological role of DNA in the living cell. This book provides a comprehensive and lucid discussion of the molecular interactions involved.

Physical Aspects of Protein Interactions

Preface This volume consists of collected papers presented at the American
Chemical Society Symposium on " Protein Interactions " which was held in Miami
Beach , Florida , September 12 - 13 , 1978 . The emphasis of the meeting and
this ...

Author: Nicholas Catsimpoolas

Publisher: North-Holland

ISBN: UOM:39015000809676

Category: Molecular association

Page: 307

View: 348

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Nucleic Acid protein Interactions

2 , this has been explained by proposing that protein monomers line up in close
juxtaposition along a DNA strand . Due to favorable protein - protein interactions ,
an incoming 32 - protein monomer strongly prefers to bind to the 10 nucleotides ...

Author: Julius Schultz

Publisher:

ISBN: 0720440998

Category: Nucleic acids

Page: 494

View: 152

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Lipid protein Interactions

the dee lipids certai of the samples at higher lipid to protein ratio indicate that the
former is most probably the case ( Jost et al . , 1973c ) . Deuterium NMR spectra
also suggest that the degree of order of the first - shell lipid chains are less than ...

Author: Patricia C. Jost

Publisher: John Wiley & Sons

ISBN: UOM:39015001623506

Category: Lipid membranes

Page: 307

View: 144

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Gum milk Protein Interactions as Determined by Viscosity

Effect of Protein * Concentration interaction on the log viscosity of gum - milk
protein solutions ( Gum * heat * prot * conc ) 47 13 . Effect of Heat * Gum * Protein
interaction on the log viscosity of gum - milk protein solutions ( Gum * heat * prot ...

Author: Karen Ann Schmidt

Publisher:

ISBN: MINN:31951D00075350X

Category:

Page: 288

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Polyanion Plasma Protein Interactions

Studies Concerning Heparin Binding with Antithrombin and the First Component
of Complement Agarose-protein Binding E. John McKay. 70 McKay and Laurell J.
Lab . Chin Med . January , 1980 C2 and C4b by complexing with Mg ++ ions .

Author: E. John McKay

Publisher:

ISBN: UCAL:B2705109

Category: Blood proteins

Page: 52

View: 346

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In Vitro DNA protein Interactions Involving DNA from the Regulatory Regions of Estrogen Responsive Genes and Proteins from Estrogen Target Cells and Tissues

INTRODUCTION DNA - protein interactions are involved in many critical events
in an eukaryotic cell . These include the fundamental processes of DNA
replication and gene transcription . It has become increasingly clear that
processes such ...

Author: Timothy J. Schuh

Publisher:

ISBN: WISC:89090026881

Category:

Page: 574

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Protein protein Interactions in Biosynthesis of Complex Polyketides

1 Impaired Protein - Protein Interactions Within a module there is an extensive
network of protein - protein interactions which need to be optimal for robust
turnover by a module . Any imbalance may result in a kinetically impaired module
.

Author: Pawan Kumar

Publisher:

ISBN: STANFORD:36105119693211

Category:

Page: 186

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Characterization of DNA protein Interactions Involved in Marek s Disease Virus mediated Rous Sarcoma Virus Long Terminal Repeat Promoter Transactivation

Stable ELE factor binding to its own recognition sequence appears to be
enhanced by protein - protein interaction with EFI factor . In support of this , ELE
binding site alone was not able to generate any DNA - protein complex in
electrophoretic ...

Author: Wei Sun

Publisher:

ISBN: MSU:31293016914487

Category: DNA-protein interactions

Page: 258

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Detection of DNA protein Interactions by Protein DNA Cross linking

Thesis QP517 1984 G488 Detection of DNA-protein interactions by mi I in 1 1 ii ii
in ii mi ii inn i j 3 1924 001 570 401 „ DATE DUE RETURN TO ALBERT R. MANN
LIBRARY - Detection of DNA-Protein Interactions by Protein-DNA ...

Author: David Scott Gilmour

Publisher:

ISBN: CORNELL:31924001570401

Category: DNA.

Page: 360

View: 455

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Library of Congress Subject Headings

Protein binding UF Binding , Protein BT Biochemistry RT Allosteric proteins
Radioligand assay NT Carrier proteins DNA - protein interactions
Immunoenzyme technique Proteins - Affinity labeling RNA - protein interactions
Protein binding ...

Author: Library of Congress

Publisher:

ISBN: OSU:32435076471762

Category: Subject headings, Library of Congress

Page:

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Library of Congress Subject Headings

Protein binding UF Binding , Protein BT Biochemistry RT Allosteric proteins
Radioligand assay NT Carrier proteins DNA - protein interactions
Immunoenzyme technique Proteins — Affinity labeling RNA - protein interactions
Protein binding ...

Author: Library of Congress. Cataloging Policy and Support Office

Publisher:

ISBN: UOM:39015066169627

Category: Subject headings, Library of Congress

Page:

View: 962

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Protein protein Interactions

Reflecting the various advances in the field, this book provides comprehensive coverage of protein-protein interactions.

Author: Erica Golemis

Publisher: CSHL Press

ISBN: 9780879697235

Category: Science

Page: 938

View: 433

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Reflecting the various advances in the field, this book provides comprehensive coverage of protein-protein interactions. It presents a collection of the technical and theoretical issues involved in the study of protein associations, including biophysical approaches. It also offers a collection of computational methods for analyzing interactions.